This journal article describes the Center for Study of Social Policy's Youth Thrive Framework that is based on how the research on resilience, positive youth development, neuroscience, and trauma can help lead to healthy development and well-being for youth. There are multiple examples of how the Framework can be used to modify frontline practice, policy, and organizational culture. The examples rely on strong relationships and strategies based on neuroscience to alleviate the effects of trauma and especially to guide youth in foster care. This resource supports resilience.