This issue brief explores evidence-based strategies to prevent adverse childhood experiences (ACEs). Strategies include: (1) strengthening economic supports; (2) promoting social norms that protect against violence; (3) ensuring a strong start for children; (4) teaching skills to help parents and youth handle stress; (5) connecting youth to caring adults and activities; and (6) intervening to lesson effects of ACEs. Some strategies connect directly to out-of-school time while other strategies will require broader partnerships.