This brief, based on a longer white paper, identifies and summarizes key findings in the existing literature on 12 protective and promotive factors relevant to afterschool. It then presents a conceptual model for how afterschool programs can use evidence-informed practices to impact protective and promotive factors to improve three important developmental outcomes: (1) substance misuse and abuse; (2) problem behaviors; and (3) academic performance. This resource supports the COVID-19 response.